TY - JOUR
T1 - Evaluation of Novel Targets, Including CC-Chemokine Receptor 4, in Adult T-Cell Acute Lymphoblastic Leukemia/Lymphoma A Mayo Clinic Clinical and Pathologic Study
AU - Khurana, Sharad
AU - Heckman, Michael G.
AU - Craig, Fiona E.
AU - Cochuyt, Jordan J.
AU - Greipp, Patricia
AU - Rahman, Zaid Abdel
AU - Sproat, Lisa
AU - Litzow, Mark
AU - Foran, James M.
AU - Jiang, Liuyan Jennifer
N1 - Publisher Copyright:
© 2024 College of American Pathologists. All rights reserved.
PY - 2024/4
Y1 - 2024/4
N2 - • Context.—Unlike B-cell acute lymphoblastic leukemia/ lymphoma (ALL/LBL), there have been few therapeutic advances in T-cell ALL (T-ALL)/LBL, an aggressive ALL/LBL subtype. Objective.—To perform a focused tissue array study to elucidate tumor markers of therapeutic potential in T-ALL/LBL. Design.—Using immunohistochemistry, we evaluated expression of leukemic antigens of interest, specifically CC-chemokine receptor 4 (CCR4), among others, on available remnant diagnostic material, including tumor tissue slides obtained from formalin-fixed, paraffin-embedded preserved tissues. Results.—Our analysis identified, for the first time, expression of CCR4 in T-ALL/LBL in 11 of 27 cases (40.7%) and confirmed common expression of BCL2, CD38, and CD47, as reported previously. We also identified the expression of CD123 in 4 of 26 cases (15.4%), whereas BCL6 and PDL1 were expressed in a small number of T-ALL/ LBL cases. The potential novel target CCR4 was significantly more common in the Pre/Pro-T immunophenotypic subtype, 6 of 9 (66.7%, P ¼ .01). No additional differences in clinical and epidemiologic variables were noted among positive or negative CCR4 cases. Conclusions.—These findings support preclinical and clinical testing of therapies targeting CCR4, CD47, BCL2, CD38, and CD123 in T-ALL/LBL, and may help guide the development of targeted clinical trials in T-ALL/LBL, a rare disease in urgent need of novel therapies.
AB - • Context.—Unlike B-cell acute lymphoblastic leukemia/ lymphoma (ALL/LBL), there have been few therapeutic advances in T-cell ALL (T-ALL)/LBL, an aggressive ALL/LBL subtype. Objective.—To perform a focused tissue array study to elucidate tumor markers of therapeutic potential in T-ALL/LBL. Design.—Using immunohistochemistry, we evaluated expression of leukemic antigens of interest, specifically CC-chemokine receptor 4 (CCR4), among others, on available remnant diagnostic material, including tumor tissue slides obtained from formalin-fixed, paraffin-embedded preserved tissues. Results.—Our analysis identified, for the first time, expression of CCR4 in T-ALL/LBL in 11 of 27 cases (40.7%) and confirmed common expression of BCL2, CD38, and CD47, as reported previously. We also identified the expression of CD123 in 4 of 26 cases (15.4%), whereas BCL6 and PDL1 were expressed in a small number of T-ALL/ LBL cases. The potential novel target CCR4 was significantly more common in the Pre/Pro-T immunophenotypic subtype, 6 of 9 (66.7%, P ¼ .01). No additional differences in clinical and epidemiologic variables were noted among positive or negative CCR4 cases. Conclusions.—These findings support preclinical and clinical testing of therapies targeting CCR4, CD47, BCL2, CD38, and CD123 in T-ALL/LBL, and may help guide the development of targeted clinical trials in T-ALL/LBL, a rare disease in urgent need of novel therapies.
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U2 - 10.5858/arpa.2022-0482-OA
DO - 10.5858/arpa.2022-0482-OA
M3 - Article
C2 - 37522711
AN - SCOPUS:85189052386
SN - 0003-9985
VL - 148
SP - 471
EP - 475
JO - Archives of Pathology and Laboratory Medicine
JF - Archives of Pathology and Laboratory Medicine
IS - 4 April
ER -