Evaluation of long-term neurodevelopment in twin–twin transfusion syndrome after laser therapy

Nicolas Sananès, Victor Gabriele, Anne Sophie Weingertner, Rodrigo Ruano, Magdalena Sanz-Cortes, Adrien Gaudineau, Bruno Langer, Israël Nisand, Chérif Youssef Akladios, Romain Favre

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Objective: The primary objective of our study was to evaluate the long-term neurodevelopment outcome after laser surgery for twin–twin transfusion syndrome (TTTS). The secondary objective was to identify perinatal prognostic factors associated with neurodevelopmental impairment. Method: This was a single-center cohort prospective study carried out in pregnancies complicated by TTTS and treated by laser. Neurodevleopmental assesment included the administration of Ages and Stages Questionnaires® (ASQ), for the infants between 2 and 5 years of age. Results: A total of 187 patients underwent a laser for TTTS between 2004 and 2013. Significant brain lesions were detected in eight (2.9%) cases by ultrasound and/or magnetic resonance imaging including intraventricular hemorrhage, periventricular leukomalacia, and porencephaly. Questionnaires were administered to 126 children (50.4%) at 24 months or older at the moment of testing. There were 13.5% of those infants who had an abnormal ASQ (established as one area or more scoring < 2 SD) at 3.6 years ±1.3 follow-up. There was a higher rate of abnormal ASQ among the infants with a birth weight below the fifth percentile (p = 0.036). Conclusion: Twin–twin transfusion syndrome is associated with a risk of abnormal neurological development, even in case of laser surgery. Further studies are necessary to identify the risk factors for neurological impairment.

Original languageEnglish (US)
Pages (from-to)1139-1145
Number of pages7
JournalPrenatal Diagnosis
Issue number12
StatePublished - Dec 1 2016

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Genetics(clinical)


Dive into the research topics of 'Evaluation of long-term neurodevelopment in twin–twin transfusion syndrome after laser therapy'. Together they form a unique fingerprint.

Cite this