Abstract
Percutaneous coronary intervention (PCI) is a management strategy for symptomatic obstructive coronary artery disease (CAD). Despite advancements, in-stent restenosis (ISR) still imparts a 1–2% annual rate of repeat revascularization—a focus of ongoing translational research. Optical coherence tomography (OCT) provides high resolution virtual histology of stents. Our study evaluates the use of OCT for virtual histological assessment of stent healing in a rabbit aorta model, enabling complete assessment of intraluminal healing throughout the stent. ISR varies based on intra-stent location, stent length, and stent type in a rabbit model—important considerations for translational experimental design. Atherosclerosis leads to more prominent ISR proliferation independent of stent-related factors. The rabbit stent model mirrors clinical observations, while OCT-based virtual histology demonstrates utility for pre-clinical stent assessment. Pre-clinical models should incorporate clinical and stent factors as feasible to maximize translation to clinical practice. Graphical Abstract: [Figure not available: see fulltext.].
Original language | English (US) |
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Pages (from-to) | 1194-1204 |
Number of pages | 11 |
Journal | Journal of cardiovascular translational research |
Volume | 16 |
Issue number | 5 |
DOIs | |
State | Published - Oct 2023 |
Keywords
- In-stent restenosis (ISR)
- Neointima
- Optical coherence tomography (OCT)
- Percutaneous coronary intervention (PCI)
- Rabbit
- Stent
- Translational
ASJC Scopus subject areas
- Molecular Medicine
- Genetics
- Pharmaceutical Science
- Cardiology and Cardiovascular Medicine
- Genetics(clinical)