Evaluation of a novel topical essential oxygen oil for the treatment of pain in acute tendinopathy and sprains

Marco Pappagallo, John B. Leslie, Robert B. Raffa, Peter Kash, Charles Fleischer, Nicholas Sinclair, Sumedha Labhestwar, Luigi Di Lorenzo, Aaron Tabor

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Topical analgesics may play an increasingly important role in managing acute and chronic pain as acetaminophen, NSAIDs, and opioid drugs come under heightened scrutiny. This article reviews studies about essential oxygen oil, a topical over-the-counter (OTC) analgesic new to the American market but available for many years in Europe. Prospective studies evaluating the oil's safety and efficacy in acute and chronic pain patients, a dermatological study in which healthy subjects served as their own controls, and a post-marketing surveillance study were considered. These studies found the novel essential oxygen oil to be safe and effective in a variety of acute and chronic pain syndromes as well as being well tolerated with few side effects. Its mechanism of action is not understood and further study is warranted. Essential oxygen oil is safe and effective for the treatment of pain associated with many common conditions, including tendinopathy, arthritis, sprains, and others.

Original languageEnglish (US)
Pages (from-to)25-30
Number of pages6
JournalMuscles, Ligaments and Tendons Journal
Issue number1
StatePublished - Jan 2011


  • Acute pain
  • Analgesia
  • Chronic pain
  • Essential oxygen oil
  • Tendinopathy
  • Topical analgesic

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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