TY - JOUR
T1 - Estrogen and the skeleton
AU - Khosla, Sundeep
AU - Oursler, Merry Jo
AU - Monroe, David G.
N1 - Funding Information:
Supported by National Institutes of Health grants AG004875 and AR027065, and by the Kogod Center on Aging, Mayo Foundation.
PY - 2012/11
Y1 - 2012/11
N2 - Estrogen is the major hormonal regulator of bone metabolism in women and men. Therefore, there is considerable interest in unraveling the pathways by which estrogen exerts its protective effects on bone. Although the major consequence of the loss of estrogen is an increase in bone resorption, estrogen deficiency is associated with a gap between bone resorption and formation, indicating that estrogen is also important for maintaining bone formation at the cellular level. Direct estrogen effects on osteocytes, osteoclasts, and osteoblasts lead to inhibition of bone remodeling, decreased bone resorption, and maintenance of bone formation, respectively. Estrogen also modulates osteoblast/osteocyte and T-cell regulation of osteoclasts. Unraveling these pleiotropic effects of estrogen may lead to new approaches to prevent and treat osteoporosis.
AB - Estrogen is the major hormonal regulator of bone metabolism in women and men. Therefore, there is considerable interest in unraveling the pathways by which estrogen exerts its protective effects on bone. Although the major consequence of the loss of estrogen is an increase in bone resorption, estrogen deficiency is associated with a gap between bone resorption and formation, indicating that estrogen is also important for maintaining bone formation at the cellular level. Direct estrogen effects on osteocytes, osteoclasts, and osteoblasts lead to inhibition of bone remodeling, decreased bone resorption, and maintenance of bone formation, respectively. Estrogen also modulates osteoblast/osteocyte and T-cell regulation of osteoclasts. Unraveling these pleiotropic effects of estrogen may lead to new approaches to prevent and treat osteoporosis.
UR - http://www.scopus.com/inward/record.url?scp=84867142227&partnerID=8YFLogxK
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U2 - 10.1016/j.tem.2012.03.008
DO - 10.1016/j.tem.2012.03.008
M3 - Review article
C2 - 22595550
AN - SCOPUS:84867142227
SN - 1043-2760
VL - 23
SP - 576
EP - 581
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 11
ER -