Esthesioneuroblastoma with distant metastases: Systematic review & meta-analysis

John P. Marinelli, Jeffrey R. Janus, Jamie J. Van Gompel, Michael Link, Robert Foote, Christine M. Lohse, Katharine A. Price, Ashish V. Chintakuntlawar

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Background: The purpose of this study was to determine the clinical outcomes and review the management strategies for metastatic esthesioneuroblastoma. Methods: We conducted a systematic review and meta-analysis. Results: Forty-eight studies totaling 118 patients met inclusion criteria. Chemotherapy in combination with surgery and/or radiation exhibited the best overall survival when compared to monotherapy and no treatment (P <.001). However, most patients (66%) received either monotherapy or no therapy. The number and location of metastases among the 3 treatment groups did not significantly differ (P =.85). Treatment modality remained significantly associated with overall survival on multivariable analysis (P <.001). Platinum-based chemotherapy was most commonly utilized but did not provide a survival benefit when compared with all other regimens (P =.88). Conclusion: Distant metastases with esthesioneuroblastoma portend a poor prognosis. Chemotherapy in combination with surgery and/or radiation was associated with improved overall survival. Further research into the optimal systemic therapeutic regimen for patients with distant metastases is critical.

Original languageEnglish (US)
Pages (from-to)2295-2303
Number of pages9
JournalHead and Neck
Issue number10
StatePublished - Oct 1 2018


  • advanced disease
  • esthesioneuroblastoma
  • meta-analysis
  • metastatic
  • olfactory neuroblastoma

ASJC Scopus subject areas

  • Otorhinolaryngology


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