Essential tremor: Phenotypic expression in a clinical cohort

N. R. Whaley, John D. Putzke, Yasuhiko Baba, Zbigniew K. Wszolek, Ryan J. Uitti

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


Objectives: Examine the characteristics of an essential tremor (ET) clinical cohort including base-rate variability of several commonly accepted diagnostic criteria. Methods: A clinical series of 487 consecutive individuals diagnosed with ET were included for study. Results: The sample was 53% male, had a mean age of onset of 52, and a mean age of 71. Half of the sample had a family history of ET. Half presented with asymmetrical disease and tremor affected the arms (97%), voice (62%), and head or neck (48%). There was considerable variability in the base rate of individuals fulfilling various commonly used diagnostic criteria of ET. Conclusion: The sample was deemed representative of ET clinical cohorts. Asymmetric disease was common, and there was considerable base-rate variation across traditional ET diagnostic criteria.

Original languageEnglish (US)
Pages (from-to)333-339
Number of pages7
JournalParkinsonism and Related Disorders
Issue number6
StatePublished - Aug 2007


  • Clinical features
  • Essential tremor
  • Phenotype

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology


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