Essential role for histone deacetylase 11 (HDAC11) in neutrophil biology

Eva Sahakian, Jie Chen, John J. Powers, Xianghong Chen, Kamira Maharaj, Susan L. Deng, Alex N. Achille, Maritza Lienlaf, Hong Wei Wang, Fengdong Cheng, Andressa L. Sodré, Allison Distler, Limin Xing, Patricio Perez-Villarroel, Sheng Wei, Alejandro Villagra, Ed Seto, Eduardo M. Sotomayor, Pedro Horna, Javier Pinilla-Ibarz

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Epigenetic changes in chromatin structure have been recently associated with the deregulated expression of critical genes in normal and malignant processes. HDAC11, the newest member of the HDAC family of enzymes, functions as a negative regulator of IL-10 expression in APCs, as previously described by our lab. However, at the present time, its role in other hematopoietic cells, specifically in neutrophils, has not been fully explored. In this report, for the first time, we present a novel physiologic role for HDAC11 as a multifaceted regulator of neutrophils. Thus far, we have been able to demonstrate a lineage-restricted overexpression of HDAC11 in neutrophils and committed neutrophil precursors (promyelocytes). Additionally, we show that HDAC11 appears to associate with the transcription machinery, possibly regulating the expression of inflammatory and migratory genes in neutrophils. Given the prevalence of neutrophils in the peripheral circulation and their central role in the first line of defense, our results highlight a unique and novel role for HDAC11. With the consideration of the emergence of new, selective HDAC11 inhibitors, we believe that our findings will have significant implications in a wide range of diseases spanning malignancies, autoimmunity, and inflammation.

Original languageEnglish (US)
Pages (from-to)475-486
Number of pages12
JournalJournal of Leukocyte Biology
Issue number2
StatePublished - Aug 2017


  • Epigenetics
  • Gene regulation
  • Innate immunity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology


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