Epithelial-fibroblast interactions in response to mechanical stresses in the airways: an in vitro study

Melody Swartz, Daniel Tschumperlin, Barbara Ressler, Roger Kamm, Jeffrey Drazen

Research output: Chapter in Book/Report/Conference proceedingConference contribution


A study was carried out to investigate the effects of mechanical forces on matrix production in the airways using novel in vitro techniques. Focus was on the communication between airway epithelial cells, which are subject to normal stresses, and fibroblasts, which are primarily responsible for the remodeling of the extracellular matrix. The epithelial cells were subjected to static or dynamic air pressure differentials of 0-20 cm water for 8 hours while the fibroblasts remained unstressed. Response was measured in terms of direct production and degradation of matrix molecules by both cell types as well as changes in expression of signaling molecules.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Number of pages2
ISBN (Print)0791816117
StatePublished - 1999
Event1999 Bioengineering Conference - Big Sky, MT, USA
Duration: Jun 16 1999Jun 20 1999


Other1999 Bioengineering Conference
CityBig Sky, MT, USA

ASJC Scopus subject areas

  • General Engineering


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