Epidemiology of endometrial carcinoma: Etiologic importance of hormonal and metabolic influences

Ashley S. Felix, Hannah P. Yang, Daphne W. Bell, Mark E. Sherman

Research output: Chapter in Book/Report/Conference proceedingChapter

39 Scopus citations


Endometrial carcinoma is the most common gynecologic cancer in developed nations, and the annual incidence is projected to increase, secondary to the high prevalence of obesity, a strong endometrial carcinoma risk factor. Although endometrial carcinomas are etiologically, biologically, and clinically diverse, hormonal and metabolic mechanisms are particularly strongly implicated in the pathogenesis of endometrioid carcinoma, the numerically predominant subtype. The centrality of hormonal and metabolic disturbances in the pathogenesis of endometrial carcinoma, combined with its slow development from well-characterized precursors in most cases, offers a substantial opportunity to reduce endometrial carcinoma mortality through early detection, lifestyle modification, and chemoprevention. In this chapter, we review the epidemiology of endometrial carcinoma, emphasizing theories that link risk factors for these tumors to hormonal and metabolic mechanisms. Future translational research opportunities related to prevention are discussed.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Number of pages44
StatePublished - Jan 1 2017

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Adipokines
  • Endometrial carcinoma
  • Estrogen
  • Hormones
  • Incidence trend
  • Infl ammation
  • Insulin
  • Progesterone
  • Risk factors

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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