TY - JOUR
T1 - Epidemiology of amyotrophic lateral sclerosis in Minnesota
T2 - A year-long population based study
AU - Harper, Caitlin J.
AU - Sorenson, Eric J.
AU - Mandrekar, Jay
N1 - Publisher Copyright:
© 2015 Informa Healthcare.
PY - 2015/11/27
Y1 - 2015/11/27
N2 - This is the largest population based study of ALS in the U.S., encompassing the population of Minnesota (> 5.4 million people) from July 2013 to July 2014. Data on gender, age at diagnosis, and residential county were collected for all Minnesota residents who registered with the Minnesota/North Dakota/South Dakota chapter of the ALS Association from July 2013 to July 2014. Incidence rates were calculated as the number of new cases of ALS per 100,000 people per year. The standardized incidence rates for the 2013 U.S. population and the 2013 European standard population were also reported. Results showed that the crude incidence rate of ALS was 2.2 cases per 100,000 person-years. Incidence increased with age, peaking at 70-79 years (8.3 per 100,000) with mean age at diagnosis 64 years, and was greater in males (2.4 per 100,000) than in females (1.5 per 100,000). Standardized incidence rates for the 2013 U.S. and European standard population were 2.2 and 2.39 cases per 100,000 person-years, respectively. In conclusion, the overall incidence and age and gender patterns of ALS in Minnesota are comparable to those reported by European studies (1-5).
AB - This is the largest population based study of ALS in the U.S., encompassing the population of Minnesota (> 5.4 million people) from July 2013 to July 2014. Data on gender, age at diagnosis, and residential county were collected for all Minnesota residents who registered with the Minnesota/North Dakota/South Dakota chapter of the ALS Association from July 2013 to July 2014. Incidence rates were calculated as the number of new cases of ALS per 100,000 people per year. The standardized incidence rates for the 2013 U.S. population and the 2013 European standard population were also reported. Results showed that the crude incidence rate of ALS was 2.2 cases per 100,000 person-years. Incidence increased with age, peaking at 70-79 years (8.3 per 100,000) with mean age at diagnosis 64 years, and was greater in males (2.4 per 100,000) than in females (1.5 per 100,000). Standardized incidence rates for the 2013 U.S. and European standard population were 2.2 and 2.39 cases per 100,000 person-years, respectively. In conclusion, the overall incidence and age and gender patterns of ALS in Minnesota are comparable to those reported by European studies (1-5).
KW - Epidemiology
KW - risk
KW - survival
UR - http://www.scopus.com/inward/record.url?scp=84947292276&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84947292276&partnerID=8YFLogxK
U2 - 10.3109/21678421.2015.1051991
DO - 10.3109/21678421.2015.1051991
M3 - Article
C2 - 26083871
AN - SCOPUS:84947292276
SN - 2167-8421
VL - 16
SP - 520
EP - 523
JO - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
JF - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
IS - 7-8
ER -