TY - JOUR
T1 - Eosinophils and asthma
AU - Jacobsen, Elizabeth A.
AU - Ochkur, Sergei I.
AU - Lee, Nancy A.
AU - Lee, James J.
N1 - Funding Information:
We wish to thank members of both the Nancy and Jamie Lee laboratories for the wonderfully interesting and provocative discussions over the years that have made this review possible. We greatly appreciate the efforts of Dr. Helene Rosenberg for carefully reading earlier versions of this manuscript and her willingness to tell us things we didn’t want to hear. A special note of thanks must go to Dr. Gerald Gleich who has been not just a colleague, but a mentor, teacher, and close friend. His enthusiasm and support have been central events in our continued pursuit of all things eosinophil. Finally, we wish to thank our administrative staff (Linda Mardel and Peg McGarry) whose efforts all too often go overlooked. The work presented was supported by the Mayo Foundation, and American Heart Association grant to JJL (AHA045580Z) and NAL (AHA0555639Z), as well as NIH grants to JJL (HL065228, K26RR019709-02) and NAL (HL058723).
PY - 2007/4
Y1 - 2007/4
N2 - Recruitment and activation of eosinophils into the airways of asthma patients is suggested to be a contributing causative agent in the histopathologies and lung dysfunction that are characteristic of asthma. Recent studies in mouse models of asthma and in human patients implicate eosinophils in immune regulation and remodeling in the lung in addition to their hypothesized role as destructive agents. Specifically, eosinophils not only participate in release of granule proteins, lipid mediators, reactive oxygen species, cytokines, and growth factors but also function through complex cell-cell interactions to elicit chronic T helper 2 inflammation in the lung. This review highlights the roles of eosinophils in asthma.
AB - Recruitment and activation of eosinophils into the airways of asthma patients is suggested to be a contributing causative agent in the histopathologies and lung dysfunction that are characteristic of asthma. Recent studies in mouse models of asthma and in human patients implicate eosinophils in immune regulation and remodeling in the lung in addition to their hypothesized role as destructive agents. Specifically, eosinophils not only participate in release of granule proteins, lipid mediators, reactive oxygen species, cytokines, and growth factors but also function through complex cell-cell interactions to elicit chronic T helper 2 inflammation in the lung. This review highlights the roles of eosinophils in asthma.
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U2 - 10.1007/s11882-007-0026-y
DO - 10.1007/s11882-007-0026-y
M3 - Review article
C2 - 17504657
AN - SCOPUS:34247511709
SN - 1529-7322
VL - 7
SP - 18
EP - 26
JO - Current Allergy and Asthma Reports
JF - Current Allergy and Asthma Reports
IS - 1
ER -