Eosinophillic myocarditis secondary to metastatic melanoma

Robyn E. Bryde, Jordan C. Ray, Keith A. Sacco, Brian Shapiro, Leslie Cooper

Research output: Contribution to journalArticlepeer-review


Eosinophilic myocarditis is a rare form of myocarditis that may manifest from cancer-mediated inflammation. A case of eosinophilic myocarditis secondary to metastatic melanoma is described; metastatic melanoma can cause a T helper type 2 lymphocyte–mediated increase in circulating levels of interleukin-5, which is known to stimulate eosinophil proliferation resulting in myocardial inflammation and fibrosis. Cardiac imaging with transesophageal echocardiography revealed a large immobile left ventricular apical thrombus. Cardiac MRI was then performed and revealed enhancing fibrosis along the endocardial surface.

Original languageEnglish (US)
Article numbere190076
JournalRadiology: Cardiothoracic Imaging
Issue number4
StatePublished - Oct 2019

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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