Eosinophilic Polymyositis in a Mouse

Lisa A. Krugner-Higby, Annette Gendron, Theodore Garland, Patrick A. Carter, John G. Swallow, James J. Lee

Research output: Contribution to journalArticlepeer-review


Idiopathic eosinophilic polymyositis has been described in human beings and dogs, but has not been previously diagnosed in a rodent. A Swiss-derived mouse was submitted for necropsy because of weakness, anorexia, and difficulty righting itself when rolled onto its back. No gross lesions were apparent. Microscopically, there were accumulations of eosinophils in skeletal muscle and heart. Focal, myofiber necrosis and degeneration were associated with the cellular infiltrates in these tissues. No parasites were found associated with these lesions. The disease in this mouse may have had a genetic or common-exposure component.

Original languageEnglish (US)
Pages (from-to)94-97
Number of pages4
JournalContemporary Topics in Laboratory Animal Science
Issue number6
StatePublished - Dec 1 1998

ASJC Scopus subject areas

  • Animal Science and Zoology
  • General Veterinary


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