Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management

Matthieu Groh, Christian Pagnoux, Chiara Baldini, Elisabeth Bel, Paolo Bottero, Vincent Cottin, Klaus Dalhoff, Bertrand Dunogué, Wolfgang Gross, Julia Holle, Marc Humbert, David Jayne, J. Charles Jennette, Romain Lazor, Alfred Mahr, Peter A. Merkel, Luc Mouthon, Renato Alberto Sinico, Ulrich Specks, Augusto VaglioMichael E. Wechsler, Jean François Cordier, Loïc Guillevin

Research output: Contribution to journalArticlepeer-review

196 Scopus citations


Objective To develop disease-specific recommendations for the diagnosis and management of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) (EGPA). Methods The EGPA Consensus Task Force experts comprised 8 pulmonologists, 6 internists, 4 rheumatologists, 3 nephrologists, 1 pathologist and 1 allergist from 5 European countries and the USA. Using a modified Delphi process, a list of 40 questions was elaborated by 2 members and sent to all participants prior to the meeting. Concurrently, an extensive literature search was undertaken with publications assigned with a level of evidence according to accepted criteria. Drafts of the recommendations were circulated for review to all members until final consensus was reached. Results Twenty-two recommendations concerning the diagnosis, initial evaluation, treatment and monitoring of EGPA patients were established. The relevant published information on EGPA, antineutrophil-cytoplasm antibody-associated vasculitides, hypereosinophilic syndromes and eosinophilic asthma supporting these recommendations was also reviewed. Discussion These recommendations aim to give physicians tools for effective and individual management of EGPA patients, and to provide guidance for further targeted research.

Original languageEnglish (US)
Pages (from-to)545-553
Number of pages9
JournalEuropean Journal of Internal Medicine
Issue number7
StatePublished - Sep 1 2015


  • Anti-neutrophil cytoplasm antibody-associated vasculitis
  • Asthma
  • Churg-Strauss syndrome
  • Eosinophilia
  • Eosinophilic granulomatosis with polyangiitis
  • Recommendations

ASJC Scopus subject areas

  • Internal Medicine


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