Eosinophilic granulomatosis with polyangiitis and diffuse gastrointestinal involvement

Diana L. Franco, Kevin Ruff, Lester Mertz, Dora M. Lam-Himlin, Russell Heigh

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Eosinophilic granulomatosis with polyangiitis (EGPA), formerly named Churg-Strauss syndrome, is a rare systemic small- and medium-sized-vessel vasculitis, characterized by the presence of severe asthma as well as blood and tissue eosinophilia. Gastrointestinal (GI) symptoms, like diarrhea and abdominal pain, are common; however, there are few reports of histologic evidence of GI involvement. We report the case of a patient on treatment for EGPA who presented with recurrent small bowel obstruction and choledocholithiasis. Biopsies of the esophagus, small bowel and common bile duct showed diffuse eosinophilia, with clear EGPA in the GI tract. Improved awareness of GI EGPA may allow for timely management of this disorder.

Original languageEnglish (US)
Pages (from-to)329-336
Number of pages8
JournalCase Reports in Gastroenterology
Issue number3
StatePublished - Apr 12 2014


  • Cholangitis
  • Eosinophilic granulomatosis with polyangiitis
  • Gastrointestinal tract
  • Small bowel obstruction

ASJC Scopus subject areas

  • Gastroenterology


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