Eosinopenia of acute infection. Production of eosinopenia by chemotactic factors of acute inflammation

D. A. Bass, T. A. Gonwa, P. Szejda, M. S. Cousart, L. R. DeChatelet, C. E. McCall

Research output: Contribution to journalArticlepeer-review

97 Scopus citations


One distinctive aspect of the response to acute inflammation involves a rapid and persistent decrease in the numbers of circulating eosinophils, yet the mechanisms of this eosinopenia undefined. One possibility is that the abrupt eosinopenia may be the result of release of small amounts of the chemotactic factors of acute inflammation into the circulation. These studies were designed to examine the numbers of circulating eosinophils after an intravenous injection of zymosan-activated serum, partially purified C5a or the synthetic peptide, N-formyl-methionyl-leucyl-phenylalanine. Each of these factors caused a virtual disappearance of circulating eosinophils within 1 min, a transient return of eosinophils to ~50% of control levels after 10-90 min, and a subsequent decrease which persisted for 5 h. In contrast, the numbers of circulating heterophils, although dropping transiently, rapidly returned and rose to elevated levels for 6 h after injection. The response was not caused by adrenal mediation as it occurred normally in adrenalectomized rabbits. Two chemotaxins of allergic inflammation, histamine and the tetrapeptide valine-glycine-serine-glutamic acid, did not cause significant eosinopenia. Circulating granulocytes of patients undergoing hemodialysis, which has been reported to activate complement, demonstrated similar eosinopenic and neutropenic-neutrophilic responses. Thus, in rabbits and in man, intravascular activation or injection of chemotactic factors (C5a or N-formyl-methionyl-leucyl-phenylalanine) causes a brief, nonspecific granulocytopenia followed by a prolonged eosinopenic-neutrophilic response analogous to that seen during acute infection.

Original languageEnglish (US)
Pages (from-to)1265-1271
Number of pages7
JournalJournal of Clinical Investigation
Issue number6
StatePublished - 1980

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Eosinopenia of acute infection. Production of eosinopenia by chemotactic factors of acute inflammation'. Together they form a unique fingerprint.

Cite this