Abstract
Increasing evidence suggests that a subset of gastrointestinal motility disorders is associated with the presence of circulating antibodies. These antibodies are directed against various molecular targets, the best known being anti-neuronal nuclear antibody (ANNA-1 or anti-Hu) associated with paraneoplastic motility disorders. There is also evidence that the presence of distinct autoantibody profiles is associated with non-paraneoplastic motility disorders. This review focuses on the types of antibodies associated with gastrointestinal motility disorders and the significance of these antibodies. Algorithms are suggested for the work-up and treatment of patients with circulating antibodies associated with gastrointestinal motility disorders.
Original language | English (US) |
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Pages (from-to) | 397-410 |
Number of pages | 14 |
Journal | Gastroenterology Clinics of North America |
Volume | 37 |
Issue number | 2 |
DOIs | |
State | Published - Jun 2008 |
ASJC Scopus subject areas
- Gastroenterology