Enhancing the Trustworthiness of the Endocrine Society's Clinical Practice Guidelines

Christopher R. McCartney, Maureen D. Corrigan, Matthew T. Drake, Ghada El-Hajj Fuleihan, Mary T. Korytkowski, Robert W. Lash, David C. Lieb, Anthony L. McCall, Ranganath Muniyappa, Thomas Piggott, Nancy Santesso, Holger J. Schünemann, Wojtek Wiercioch, Marie E. McDonnell, M. Hassan Murad

Research output: Contribution to journalArticlepeer-review


In an effort to enhance the trustworthiness of its clinical practice guidelines, the Endocrine Society has recently adopted new policies and more rigorous methodologies for its guideline program. In this Clinical Practice Guideline Communication, we describe these recent enhancements-many of which reflect greater adherence to the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach to guideline development-in addition to the rationale for such changes. Improvements to the Society's guideline development practices include, but are not limited to, enhanced inclusion of nonendocrinologist experts, including patient representatives, on guideline development panels; implementation of a more rigorous conflict/duality of interest policy; a requirement that all formal recommendations must be demonstrably underpinned by systematic evidence review; the explicit use of GRADE Evidence-to-Decision frameworks; greater use and explanation of standardized guideline language; and a more intentional approach to guideline updating. Lastly, we describe some of the experiential differences our guideline readers are most likely to notice.

Original languageEnglish (US)
Pages (from-to)2129-2138
Number of pages10
JournalJournal of Clinical Endocrinology and Metabolism
Issue number8
StatePublished - Aug 1 2022


  • GRADE approach
  • clinical practice guidelines
  • practice guidelines
  • systematic reviews
  • trust
  • trustworthiness

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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