Enhanced Impedance Flow Cytometry via Acoustic-Driven Microparticle Focusing in Microchannels

Peng Zhou, Yingming Xu, Terrence Simon, Martin E. Fernandez-Zapico, Wen Wee Ma, Tianhong Cui

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This work presents a new microparticle focusing technique for Impedance Flow Cytometry (IFC) affected by acoustic excitation in a microchannel with air pockets. Particle focusing is achieved by utilizing the secondary flow generated by the vibration to alter the trajectories of particles in microchannels. Different excitation frequencies are used to drive the vibration of a gas-liquid interface and two particle focusing modes are achieved under different excitation frequencies. The impedance measurement is performed downstream to verify its applicability to IFC. The results indicate that when particle focusing is present, there is a significant reduction in the standard deviation of impedance changes caused by 10 μm microspheres, dropping from 0.0096 mV to 0.0021 mV compared to non-oscillating conditions.

Original languageEnglish (US)
Title of host publicationIEEE 37th International Conference on Micro Electro Mechanical Systems, MEMS 2024
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1130-1133
Number of pages4
ISBN (Electronic)9798350357929
DOIs
StatePublished - 2024
Event37th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2024 - Austin, United States
Duration: Jan 21 2024Jan 25 2024

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)1084-6999

Conference

Conference37th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2024
Country/TerritoryUnited States
CityAustin
Period1/21/241/25/24

Keywords

  • Acoustic Excitation
  • Air Pockets
  • Impedance Flow Cytometry
  • Particle Focusing

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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