Endovascular treatment of experimental aneurysms by use of fibroblast-coated platinum coils: An angiographic and histopathologic study

Daying Dai, Yong Hong Ding, Mark A. Danielson, Ramanathan Kadirvel, Larry W. Hunter, Wen Zhi Zhan, Gregory A. Helm, Debra A. Lewis, Harry J. Cloft, Gary C. Sieck, David F. Kallmes

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


BACKGROUND AND PURPOSE - The purpose of this study was to determine whether implanting exogenous fibroblasts on platinum coils could enhance intra-aneurysmal fibrosis. Hypotheses included: (1) fibroblast-coated (FBC) platinum coils can improve angiographic results after embolization; and (2) FBC platinum coils can accelerate histological healing of embolized aneurysms. METHODS - Experimental aneurysms in rabbits were embolized with control platinum coils (n=18) or FBC coils (n=18). Subjects were euthanized at 14 days, 1 month, 3 months and 6 months after implantation. Digital subtraction angiography was used to evaluate stability after embolization. Histological samples were examined with a grading system (range, 0 to 12) based on neck and dome healing. RESULTS - Histology total scores and fibrosis ratio at 14 days were significantly greater in the FBC coil group compared with controls (6.6±1.9 versus 2.5±1.1, 1.2±0.6% versus 0.2±0.3%, respectively; P=0.0090). Cavities embolized with FBC coils showed cellular proliferation and thrombus organization, with an endothelialized membrane bridging the neck. There were no differences between groups in the later timepoints. The FBC coil group showed radiographic stability in 11 (61%) cases, coil compaction in 2 (11%) cases, and progressive occlusion in 5 (28%) cases. No progressive occlusion was seen in controls; 3 (17%) of 18 control cases exhibited coil compaction (P=0.0546). CONCLUSIONS - FBC coils can accelerate early histological healing compared with control coils in the rabbit aneurysm model.

Original languageEnglish (US)
Pages (from-to)170-176
Number of pages7
Issue number1
StatePublished - Jan 2007


  • Angiography
  • Experimental aneurysm
  • Fibroblast coated coil
  • Histology
  • Rabbit

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing


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