Endotherapy for and tailored approaches to treating GERD, and refractory GERD

G. Richard Locke, John Horwhat, Hiroshi Mashimo, Edoardo Savarino, Patrizia Zentilin, Vincenzo Savarino, Frank Zerbib, Steven P. Armbruster, Roy K. Wong, Fouad Moawad

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


This paper presents commentaries on how endoluminal antireflux procedures compare to laparoscopic fundoplication; new endoscopic procedures being studied to treat refractory gastroesophageal reflux disease (GERD); the new Stretta; the relationship between obesity and proton pump inhibitor (PPI) resistance; data concerning acid hypersensitivity and sensory receptors (vallinoid, TRPV1) causing refractory GERD; whether microscopic esophagitis is relevant in determining symptoms of non-erosive reflux disease (NERD); how concomitant functional gastrointestinal disorders affect the PPI response in NERD; the evidence that a functional esophagus is associated with inflammatory bowel syndrome (IBS); the role of GABA agonists in the treatment of refractory GERD; the role of biofeedback and antidepressants in refractory GERD; and endoluminal fundoplication using the EsophyX device.

Original languageEnglish (US)
Pages (from-to)166-186
Number of pages21
JournalAnnals of the New York Academy of Sciences
Issue number1
StatePublished - Oct 2013


  • Antidepressants
  • Functional heartburn
  • GABA agonists
  • IBS
  • NERD
  • PPI
  • TRPV1

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • History and Philosophy of Science


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