Endothelium-derived factors of veins: Implications in development of venous disease

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Vascular endothelia release paracrine factors which affect aggregation of platelets and the tone and proliferation of the underlying smooth muscle. These endothelium-derived factors are released in response to two limbs of Virchow's triad: (1) substances associated with the coagulation cascade, and (2) changes in blood flow. Therefore, dysfunction of the venous endothelium could contribute to development of deep venous thrombosis and structural disease of the venous wall.

Original languageEnglish (US)
Pages (from-to)110-114
Number of pages5
JournalInternational Journal of Angiology
Issue number2
StatePublished - 1997

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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