Endothelium-dependent contraction to stretch in canine basilar arteries

Z. S. Katusic, J. T. Shepherd, P. M. Vanhoutte

Research output: Contribution to journalArticlepeer-review

160 Scopus citations


Stretch applied to isolated canine basilar arteries caused the development of active tension in rings with endothelium but not in those in which the endothelium had been removed. Blockade of calcium entry with diltiazem or inhibition of cyclooxygenase with indomethacin abolished the endothelium-dependent response to stretch. These observations suggest that the endothelium may contribute to the autoregulation of cerebral blood flow during increases in transmural pressure by the increased production and/or release of prostaglandins, which causes activation of the underlying vascular smooth muscle.

Original languageEnglish (US)
Pages (from-to)H671-H673
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Issue number3 (21/3)
StatePublished - 1987

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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