Endosomal protein traffic meets nuclear signal transduction head on

Bruce Horazdovsky

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Rab5 plays a key role in controlling protein traffic through the early stages of the endocytic pathway. Previous studies on the modulators and effectors of Rab5 protein function have tied the regulation of several signal transduction pathways to the movement of protein through endocytic compartments. In the February 6, 2004, issue of Cell, Miaczynska et al. describe a surprising new link between Rab5 function and the nucleus by uncovering two new Rab5 effectors as potential regulators of the nucleosome remodeling and histone deacetylase protein complex NuRD/MeCP1.

Original languageEnglish (US)
Pages (from-to)161-162
Number of pages2
JournalDevelopmental Cell
Issue number2
StatePublished - Feb 2004

ASJC Scopus subject areas

  • Molecular Biology
  • General Biochemistry, Genetics and Molecular Biology
  • Developmental Biology
  • Cell Biology


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