Abstract
Endogenous superantigen-mediated thymic negative selection resulted in a paucity of mature T cells bearing T-cell receptor (TCR) Vβ8 in the periphery. Consequently, the magnitude of immune response to exogenous superantigen staphylococcal enterotoxin B, which activates TCR Vβ8 + T cells, was significantly reduced and conferred protection from superantigen-induced mortality.
Original language | English (US) |
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Pages (from-to) | 1119-1122 |
Number of pages | 4 |
Journal | Clinical and Diagnostic Laboratory Immunology |
Volume | 12 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2005 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Clinical Biochemistry
- Microbiology (medical)