Endogenous superantigens shape response to exogenous superantigens

Govindarajan Rajagopalan, Manisha Singh, Moon M. Sen, Narayana S. Murali, Karl A. Nath, Chella S. David

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Endogenous superantigen-mediated thymic negative selection resulted in a paucity of mature T cells bearing T-cell receptor (TCR) Vβ8 in the periphery. Consequently, the magnitude of immune response to exogenous superantigen staphylococcal enterotoxin B, which activates TCR Vβ8 + T cells, was significantly reduced and conferred protection from superantigen-induced mortality.

Original languageEnglish (US)
Pages (from-to)1119-1122
Number of pages4
JournalClinical and Diagnostic Laboratory Immunology
Issue number9
StatePublished - Sep 2005

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)


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