Emerging drugs for the treatment of tobacco dependence: 2014 update

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Introduction: Tobacco dependence remains a global epidemic and the largest preventable cause of morbidity and mortality around the world. Smoking cessation has benefits at all ages but remains challenging for several reasons, among which are the complexities of nicotine addiction and limitations of available pharmacotherapies. Areas covered: This review summarizes current and emerging pharmacotherapies for the treatment of tobacco dependence, including first- and second-line recommended agents. Medications with alternative primary indications that have been investigated as potential treatments for tobacco dependence are also discussed. Articles reviewed were obtained through searches of PubMed, Ovid MEDLINE, ClinicalTrials.gov and the Pharmaprojects database. Expert opinion: Current evidence suggests that the two most effective pharmacotherapies to treat tobacco dependence are varenicline and combination nicotine replacement therapy. Alternative agents investigated demonstrate mixed rates of success in achieving long-term abstinence from smoking. No single pharmacotherapy will serve as a universally successful treatment given the complex underpinnings of tobacco dependence and individuality of smokers. The ultimate goal of tobacco research with respect to pharmacotherapeutic development continues to be providing clinicians with an armamentarium of drugs to choose from allowing for tailoring of treatment for smokers.

Original languageEnglish (US)
Pages (from-to)243-260
Number of pages18
JournalExpert Opinion on Emerging Drugs
Issue number2
StatePublished - Jun 2014


  • Atomoxetine
  • Baclofen
  • Bupropion
  • Buspirone
  • Carvedilol
  • Clonidine
  • Cytisine
  • D-cycloserine
  • EVT 302
  • Emerging pharmacotherapies
  • GSK598809
  • Labetalol
  • Lobeline
  • Mecamylamine
  • N-acetylcysteine
  • Naltrexone
  • Nicotine replacement therapy

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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