Electrophysiological findings in a cohort of old polio survivors

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


A population-based cohort of poliomyelitis survivors was established and followed for 15 years (mean time since polio was 40 years). Over time, the cohort demonstrated a modest decline in summated compound muscle action potential amplitudes (CMAP) and a moderate decline in the summated motor unit number estimates (MUNE). There was no association between symptoms of late deterioration and magnitude of decline. Rather, the presence of these symptoms was associated with the magnitude of the residual deficits. Two patterns of neuron loss were modeled (linear and proportional decline). The summated MUNE was a more sensitive measure of loss of motor units than was the summated CMAP and appears to be a more valid measure of attritional loss of anterior horn cells. Of these two models of neuron loss, the proportional loss of motor neurons was a better fit of the data than a linear loss.

Original languageEnglish (US)
Pages (from-to)241-246
Number of pages6
JournalJournal of the Peripheral Nervous System
Issue number3
StatePublished - Sep 2006


  • Electrophysiology
  • Epidemiology
  • Neuromuscular disease
  • Poliomyelitis

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Neurology


Dive into the research topics of 'Electrophysiological findings in a cohort of old polio survivors'. Together they form a unique fingerprint.

Cite this