Electrical activity modulates growth cone guidance by diffusible factors

Guo Li Ming, John Henley, Marc Tessier-Lavigne, Hong Jun Song, Mu Ming Poo

Research output: Contribution to journalArticlepeer-review

203 Scopus citations


Brief periods of electrical stimulation of cultured Xenopus spinal neurons resulted in a marked alteration in the turning responses of the growth cone induced by gradients of attractive or repulsive guidance cues. Netrin-1-induced attraction was enhanced, and the repulsion induced by myelin-associated glycoprotein (MAG) or myelin membrane fragments was converted to attraction. The effect required the presence of extracellular Ca2+ during electrical stimulation and appeared to be mediated by an elevation of both cytoplasmic Ca2+ and cAMP. Thus, electrical activity may influence the axonal path finding of developing neurons, and intermittent electrical stimulation may be effective in promoting nerve regeneration after injury.

Original languageEnglish (US)
Pages (from-to)441-452
Number of pages12
Issue number2
StatePublished - 2001

ASJC Scopus subject areas

  • General Neuroscience


Dive into the research topics of 'Electrical activity modulates growth cone guidance by diffusible factors'. Together they form a unique fingerprint.

Cite this