Efficient delivery of gold nanoparticles by dual receptor targeting

Sanjib Bhattacharyya; Jameel Ahmad Khan; Geoffry L. Curran; J. David Robertson; Resham Bhattacharya; Priyabrata Mukherjee

doi:10.1002/adma.201102287

Efficient delivery of gold nanoparticles by dual receptor targeting

Sanjib Bhattacharyya, Jameel Ahmad Khan, Geoffry L. Curran, J. David Robertson, Resham Bhattacharya, Priyabrata Mukherjee

Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

The fabrication and characterization of a dual receptor targeted system (DRTS) are described. It is demonstrated that DRTS is more efficient at delivering gold nanoparticles (AuNPs) to ovarian cancer cells expressing epidermal growth factor receptor (EGFR) and folate receptor (FR) than their corresponding single-receptor-targeting systems (SRTS).

Original language	English (US)
Pages (from-to)	5034-5038
Number of pages	5
Journal	Advanced Materials
Volume	23
Issue number	43
DOIs	https://doi.org/10.1002/adma.201102287
State	Published - Nov 16 2011

Keywords

biomedical applications
epidermal growth factor receptors (EGFR)
folate receptors (FR)
gold nanoparticles

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201102287

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author = "Sanjib Bhattacharyya and Khan, {Jameel Ahmad} and Curran, {Geoffry L.} and Robertson, {J. David} and Resham Bhattacharya and Priyabrata Mukherjee",

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AU - Curran, Geoffry L.

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AU - Bhattacharya, Resham

AU - Mukherjee, Priyabrata

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AB - The fabrication and characterization of a dual receptor targeted system (DRTS) are described. It is demonstrated that DRTS is more efficient at delivering gold nanoparticles (AuNPs) to ovarian cancer cells expressing epidermal growth factor receptor (EGFR) and folate receptor (FR) than their corresponding single-receptor-targeting systems (SRTS).

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KW - epidermal growth factor receptors (EGFR)

KW - folate receptors (FR)

KW - gold nanoparticles

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Efficient delivery of gold nanoparticles by dual receptor targeting

Abstract

Keywords

ASJC Scopus subject areas

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