TY - JOUR
T1 - Effects of unilateral hyperinflation on the interpulmonary distribution of pleural pressure
AU - Hubmayr, R. D.
AU - Margulies, S. S.
PY - 1992
Y1 - 1992
N2 - Motivated by single lung transplantation, we studied the mechanics of the chest wall during single lung inflations in recumbent dogs and baboons and determined how pleural pressure (Ppl) is coupled between the hemithoraces. In one set of experiments, the distribution of Ppl was inferred from known volumes and elastic properties of each lung. In a second set of experiments, costal pleural liquid pressure (Ppl(cos)) was measured with rib capsules. Both methods revealed that the increase in Ppl over the ipsilateral or inflated lung (ΔPpl(i)) is greater than that over the contralateral or noninflated lung (ΔPpl(c)). Mean d(ΔPpl(c))/d(ΔPpl(i)) and its 95% confidence interval was 0.7 ± 0.1 in dogs and 0.5 ± 0.1 in baboons. In a third set of experiments in three dogs and three baboons, we prevented sternal displacement and exposed the abdominal diaphragm to atmospheric pressure during unilateral lung inflation. These interventions had no significant effect on Ppl coupling between the hemithoraces. We conclude that lungs of unequal size and mechanical properties need not be exposed to the same surface pressure, because thoracic midline structures and the lungs themselves resist displacement and deformation.
AB - Motivated by single lung transplantation, we studied the mechanics of the chest wall during single lung inflations in recumbent dogs and baboons and determined how pleural pressure (Ppl) is coupled between the hemithoraces. In one set of experiments, the distribution of Ppl was inferred from known volumes and elastic properties of each lung. In a second set of experiments, costal pleural liquid pressure (Ppl(cos)) was measured with rib capsules. Both methods revealed that the increase in Ppl over the ipsilateral or inflated lung (ΔPpl(i)) is greater than that over the contralateral or noninflated lung (ΔPpl(c)). Mean d(ΔPpl(c))/d(ΔPpl(i)) and its 95% confidence interval was 0.7 ± 0.1 in dogs and 0.5 ± 0.1 in baboons. In a third set of experiments in three dogs and three baboons, we prevented sternal displacement and exposed the abdominal diaphragm to atmospheric pressure during unilateral lung inflation. These interventions had no significant effect on Ppl coupling between the hemithoraces. We conclude that lungs of unequal size and mechanical properties need not be exposed to the same surface pressure, because thoracic midline structures and the lungs themselves resist displacement and deformation.
KW - chest wall mechanics
KW - mediastinal compliance
KW - single lung transplantation
UR - http://www.scopus.com/inward/record.url?scp=0026657575&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026657575&partnerID=8YFLogxK
U2 - 10.1152/jappl.1992.73.4.1650
DO - 10.1152/jappl.1992.73.4.1650
M3 - Article
C2 - 1447116
AN - SCOPUS:0026657575
SN - 0161-7567
VL - 73
SP - 1650
EP - 1654
JO - Journal of applied physiology
JF - Journal of applied physiology
IS - 4
ER -