Effects of metabolic syndrome on atherosclerosis in childhood

Muhammad Yasir Qureshi, Sarah E. Messiah, Tracie L. Miller, Steven E. Lipshultz

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Atherosclerosis is a chronic disease of the arterial wall that starts in childhood but does not usually manifest clinically until adulthood. Its progression depends on several risk factors, most of which are components of metabolic syndrome. In this chapter, we summarize the evidence of pediatric onset of atherosclerosis and discuss its pathogenesis. We also review the effects of various components of metabolic syndrome on the development of atherosclerosis and the strategies for stratifying and reducing the risk of atherosclerosis. A substantial amount of data confirms the early initiation of atherosclerosis. Therefore, earlier efforts to identify, prevent, and treat metabolic syndrome may improve the quality and length of life.

Original languageEnglish (US)
Title of host publicationPediatric Metabolic Syndrome
Subtitle of host publicationComprehensive Clinical Review and Related Health Issues
PublisherSpringer-Verlag London Ltd
Number of pages24
ISBN (Electronic)9781447123668
ISBN (Print)9781447123651
StatePublished - Jan 1 2012


  • Adolescents
  • Atherosclerosis
  • Cardiovascular risk factors
  • Metabolic syndrome
  • Pediatrics

ASJC Scopus subject areas

  • General Medicine


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