Effects of growth hormone, glucose and insulin on the factor VIII complex

G. D.O. Lowe; S. M. Middleton; I. D. Hay; G. H. Beastall; M. Singaraveloo; H. N. Cohen; J. A. Thomson; C. D. Forbes; C. R.M. Prentice

doi:10.1016/0049-3848(82)90262-6

Effects of growth hormone, glucose and insulin on the factor VIII complex

G. D.O. Lowe, S. M. Middleton, I. D. Hay, G. H. Beastall, M. Singaraveloo, H. N. Cohen, J. A. Thomson, C. D. Forbes, C. R.M. Prentice

Endocrinology, Diabetes, Metabolism, and Nutrition

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The relationship of growth hormone (GH) to the factor VIII complex (VIIIC, VIIIRAg and VIIIRRCo) was investigated. No correlation between basal levels of GH and factor VIII assays was found in 23 subjects. No significant change in factor VIII assays was observed after GH suppression by oral glucose or bromocriptine. After insulin-induced hypoglycaemia all three factor VIII assays rose and fell in parallel with GH. However, after exercise the rise in VIIIC and VIIIRAg preceded the rise in GH; and no changes in factor VIII assays were observed after administration of thyrotrophin releasing hormone (TRH) (releasing endogenous GH) or exogenous GH. These findings do not support a role for GH in the regulation of plasma levels of VIIIC, VIIIRAg or VIIIRRCo.

Original language	English (US)
Pages (from-to)	201-211
Number of pages	11
Journal	Thrombosis research
Volume	28
Issue number	2
DOIs	https://doi.org/10.1016/0049-3848(82)90262-6
State	Published - Oct 15 1982

Keywords

Factor VIII
diabetes
growth hormone
insulin

ASJC Scopus subject areas

Hematology

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10.1016/0049-3848(82)90262-6

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title = "Effects of growth hormone, glucose and insulin on the factor VIII complex",

abstract = "The relationship of growth hormone (GH) to the factor VIII complex (VIIIC, VIIIRAg and VIIIRRCo) was investigated. No correlation between basal levels of GH and factor VIII assays was found in 23 subjects. No significant change in factor VIII assays was observed after GH suppression by oral glucose or bromocriptine. After insulin-induced hypoglycaemia all three factor VIII assays rose and fell in parallel with GH. However, after exercise the rise in VIIIC and VIIIRAg preceded the rise in GH; and no changes in factor VIII assays were observed after administration of thyrotrophin releasing hormone (TRH) (releasing endogenous GH) or exogenous GH. These findings do not support a role for GH in the regulation of plasma levels of VIIIC, VIIIRAg or VIIIRRCo.",

keywords = "Factor VIII, diabetes, growth hormone, insulin",

author = "Lowe, {G. D.O.} and Middleton, {S. M.} and Hay, {I. D.} and Beastall, {G. H.} and M. Singaraveloo and Cohen, {H. N.} and Thomson, {J. A.} and Forbes, {C. D.} and Prentice, {C. R.M.}",

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AU - Lowe, G. D.O.

AU - Middleton, S. M.

AU - Hay, I. D.

AU - Beastall, G. H.

AU - Singaraveloo, M.

AU - Cohen, H. N.

AU - Thomson, J. A.

AU - Forbes, C. D.

AU - Prentice, C. R.M.

PY - 1982/10/15

Y1 - 1982/10/15

N2 - The relationship of growth hormone (GH) to the factor VIII complex (VIIIC, VIIIRAg and VIIIRRCo) was investigated. No correlation between basal levels of GH and factor VIII assays was found in 23 subjects. No significant change in factor VIII assays was observed after GH suppression by oral glucose or bromocriptine. After insulin-induced hypoglycaemia all three factor VIII assays rose and fell in parallel with GH. However, after exercise the rise in VIIIC and VIIIRAg preceded the rise in GH; and no changes in factor VIII assays were observed after administration of thyrotrophin releasing hormone (TRH) (releasing endogenous GH) or exogenous GH. These findings do not support a role for GH in the regulation of plasma levels of VIIIC, VIIIRAg or VIIIRRCo.

AB - The relationship of growth hormone (GH) to the factor VIII complex (VIIIC, VIIIRAg and VIIIRRCo) was investigated. No correlation between basal levels of GH and factor VIII assays was found in 23 subjects. No significant change in factor VIII assays was observed after GH suppression by oral glucose or bromocriptine. After insulin-induced hypoglycaemia all three factor VIII assays rose and fell in parallel with GH. However, after exercise the rise in VIIIC and VIIIRAg preceded the rise in GH; and no changes in factor VIII assays were observed after administration of thyrotrophin releasing hormone (TRH) (releasing endogenous GH) or exogenous GH. These findings do not support a role for GH in the regulation of plasma levels of VIIIC, VIIIRAg or VIIIRRCo.

KW - Factor VIII

KW - diabetes

KW - growth hormone

KW - insulin

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JO - Thrombosis research

JF - Thrombosis research

IS - 2

ER -

Effects of growth hormone, glucose and insulin on the factor VIII complex

Abstract

Keywords

ASJC Scopus subject areas

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