TY - JOUR
T1 - Effects of fatty acids on T cell function
T2 - role in atherosclerosis
AU - Reilly, Nathalie A.
AU - Lutgens, Esther
AU - Kuiper, Johan
AU - Heijmans, Bastiaan T.
AU - Wouter Jukema, J.
N1 - Publisher Copyright:
© 2021, Springer Nature Limited.
PY - 2021/12
Y1 - 2021/12
N2 - T cells are among the most common cell types present in atherosclerotic plaques and are increasingly being recognized as a central mediator in atherosclerosis development and progression. At the same time, triglycerides and fatty acids have re-emerged as crucial risk factors for atherosclerosis. Triglycerides and fatty acids are important components of the milieu to which the T cell is exposed from the circulation to the plaque, and increasing evidence shows that fatty acids influence T cell function. In this Review, we discuss the effects of fatty acids on four components of the T cell response — metabolism, activation, proliferation and polarization — and the influence of these changes on the pathogenesis of atherosclerosis. We also discuss how quiescent T cells can undergo a type of metabolic reprogramming induced by exposure to fatty acids in the circulation that influences the subsequent functions of T cells after activation, such as in atherosclerotic plaques.
AB - T cells are among the most common cell types present in atherosclerotic plaques and are increasingly being recognized as a central mediator in atherosclerosis development and progression. At the same time, triglycerides and fatty acids have re-emerged as crucial risk factors for atherosclerosis. Triglycerides and fatty acids are important components of the milieu to which the T cell is exposed from the circulation to the plaque, and increasing evidence shows that fatty acids influence T cell function. In this Review, we discuss the effects of fatty acids on four components of the T cell response — metabolism, activation, proliferation and polarization — and the influence of these changes on the pathogenesis of atherosclerosis. We also discuss how quiescent T cells can undergo a type of metabolic reprogramming induced by exposure to fatty acids in the circulation that influences the subsequent functions of T cells after activation, such as in atherosclerotic plaques.
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U2 - 10.1038/s41569-021-00582-9
DO - 10.1038/s41569-021-00582-9
M3 - Review article
C2 - 34253911
AN - SCOPUS:85109981825
SN - 1759-5002
VL - 18
SP - 824
EP - 837
JO - Nature Reviews Cardiology
JF - Nature Reviews Cardiology
IS - 12
ER -