Effects of elevated gonadotropin levels on thyroid function in the male rat

R. W. Steger, V. Chandrashekar, A. Bartke, J. Wortsman, S. C. Newton, R. C. Smallridge, J. Dietrich

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


In order to determine if thyroid disease in hypogonadal men is the result of chronic elevation of serum gonadotropins, thyroid histology and serum thyroid hormone levels were evaluated in male rats that had been castrated either 2 weeks or 15 months previously. Despite significantly elevating serum LH levels, castration did not affect thyroid structure or function. Serum total T4 levels were reduced with age in both short and long-term castrate animals but returned to the levels seen in young rats when testosterone was replaced. Testosterone replacement also increased free T4 levels in both the young and old castrate rats. Neither age nor testosterone replacement affected serum T3 or TSH levels.

Original languageEnglish (US)
Pages (from-to)85-90
Number of pages6
JournalLife Sciences
Issue number1
StatePublished - 1989

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • Pharmacology, Toxicology and Pharmaceutics(all)


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