Effects of depression on QT interval variability after myocardial infarction

Robert M. Carney, Kenneth E. Freedland, Phyllis K. Stein, Lana L. Watkins, Diane Catellier, Allan S. Jaffe, Vikram K. Yeragani

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Objectives: Clinical depression is a risk factor for cardiac mortality in patients with coronary heart disease. High QT interval variability is a risk factor for arrhythmic events, including sudden cardiac death. The purpose of this study was to determine whether depression is associated with increased QT variability in patients recovering from myocardial infarction. Methods: Twenty patients with major depression recovering from a recent myocardial infarction were matched with 20 nondepressed post-myocardial infarction patients on age and sex, and all underwent 24-hour Holter monitoring. Results: There were no differences between groups on average heart rate, heart rate variability, or other electrocardiographic measures. However, the QT interval showed significantly greater variability in the depressed than in the nondepressed group, especially at midnight and at 6:00 AM. Conclusions: Depressed post-myocardial infarction patients may be at greater risk for sudden cardiac death as a result of abnormalities in ventricular repolarization. More work is needed to determine the clinical and prognostic significance of QT variability in these patients.

Original languageEnglish (US)
Pages (from-to)177-180
Number of pages4
JournalPsychosomatic Medicine
Issue number2
StatePublished - 2003


  • Myocardial infarction
  • Psychiatric depression
  • QT interval

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health


Dive into the research topics of 'Effects of depression on QT interval variability after myocardial infarction'. Together they form a unique fingerprint.

Cite this