Effects of atrioventricular conduction delay on the outcome of cardiac resynchronization therapy

Ying Hsiang Lee, Jia Hui Wu, Samuel J. Asirvatham, Freddy Del Carpio Munoz, Tracy Webster, Kelly L. Brooke, David O. Hodge, Heather J. Wiste, Paul A. Friedman, Yong Mei Cha

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Background and purpose First-degree atrioventricular (AV) block in relation to the outcome of cardiac resynchronization therapy (CRT) has not been well examined.

Methods Patients who received a CRT defibrillator or pacemaker between January 2002 and September 2010 at Mayo Clinic were classified into 2 groups: normal PR interval and prolonged PR interval. Standard sensed (100 milliseconds) and paced (130 milliseconds) AV delay was programmed after CRT. Clinical presentations and echocardiography were assessed before CRT and at a median of 6 months after CRT.

Results The normal PR interval group (n = 199) had greater improvements in heart failure functional class (mean [SD], 0.7 [0.8] vs 0.5 [0.9]; P =.03) and left ventricular ejection fraction (9.4% [12.4%] vs 5.9% [9.5%]; P =.007) than the prolonged PR group (n = 204).

Conclusion Compared with prolonged PR interval, the presence of normal PR interval was associated with a greater improvement in heart failure.

Original languageEnglish (US)
Pages (from-to)930-935
Number of pages6
JournalJournal of Electrocardiology
Issue number6
StatePublished - Nov 1 2014


  • Atrioventricular block
  • Cardiac resynchronization
  • Dyssynchrony
  • Heart failure
  • PR interval
  • Survival

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Effects of atrioventricular conduction delay on the outcome of cardiac resynchronization therapy'. Together they form a unique fingerprint.

Cite this