Effects of apolipoprotein E-ε4 and -ε2 in amnestic mild cognitive impairment and dementia in Shanghai: SCOBHI-P

Amy R. Borenstein, James A. Mortimer, Ding Ding, Gerard D. Schellenberg, Charles Decarli, Qianhua Zhao, Cathleen Copenhaver, Qihao Guo, Shugang Chu, Douglas Galasko, David P. Salmon, Dai Qi, Yougui Wu, Ronald Petersen, Zhen Hong

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Objective: To determine apolipoprotein E (APOE)-ε4 and -ε2 frequencies and risk of mild cognitive impairment (MCI) and dementia in Shanghai, China. Methods: A total of 34 MCI and 34 dementia cases were recruited from an urban Memory Disorders Clinic and 32 controls were recruited from a residential community served by the clinic. Apolipoprotein E was genotyped using standard methods. Results: Among controls, frequencies were ε2, 0.11; ε3, 0.84; and ε4, 0.05; among MCI, 0.05, 0.77, and 0.18; and for dementia, 0.02, 0.84, and 0.15, respectively. In education-adjusted models, the odds ratio (OR) = 5.6 for dementia (95% CI = 1.09-29.3) and 4.7 for MCI (95% CI = 0.90-25.2) associated with any ε4 allele. The ε2 allele was inversely associated with dementia (OR = 0.12, 95% CI = 0.013-0.997) and MCI (OR = 0.38, 95% CI = 0.08-1.61). Conclusions: APOE-ε4 increases and -ε2 decreases the risk of dementia vs normal cognition. Similar trends were observed for amnestic mild cognitive impairment (aMCI).

Original languageEnglish (US)
Pages (from-to)233-238
Number of pages6
JournalAmerican Journal of Alzheimer's Disease and Other Dementias
Issue number3
StatePublished - May 2010


  • Apolipoprotein E
  • China
  • Dementia
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Clinical Psychology
  • General Neuroscience


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