Effects of 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate on fatty acid and glucose metabolism in perfused rat hearts determined using iodine-125 16-iodohexadecanoate

H. S.A. Sherratt; S. J. Gatley; T. R. DeGrado; C. K. Ng; J. E. Holden

doi:10.1016/0006-291X(83)91646-7

Effects of 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate on fatty acid and glucose metabolism in perfused rat hearts determined using iodine-125 16-iodohexadecanoate

H. S.A. Sherratt, S. J. Gatley, T. R. DeGrado, C. K. Ng, J. E. Holden

Radiology

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Abstract

Long-chain fatty acid oxidation by the isolated perfused rat heart was assayed by external counting using [¹²⁵I]16-iodohexadecanoic acid as substrate after administration of the hypoketonemic and hypoglycemic compound 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate to rats. Glucose metabolism was also assessed by measuring release of tritium from [2-T]glucose. The oxidation of long chain fatty acids was virtually suppressed in hearts from fed or starved rats given 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate while glucose utilization was increased 2-2.5 fold.

Original language	English (US)
Pages (from-to)	653-657
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	117
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(83)91646-7
State	Published - Dec 28 1983

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(83)91646-7

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Effects of 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate on fatty acid and glucose metabolism in perfused rat hearts determined using iodine-125 16-iodohexadecanoate. / Sherratt, H. S.A.; Gatley, S. J.; DeGrado, T. R. et al.
In: Biochemical and Biophysical Research Communications, Vol. 117, No. 3, 28.12.1983, p. 653-657.

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title = "Effects of 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate on fatty acid and glucose metabolism in perfused rat hearts determined using iodine-125 16-iodohexadecanoate",

abstract = "Long-chain fatty acid oxidation by the isolated perfused rat heart was assayed by external counting using [125I]16-iodohexadecanoic acid as substrate after administration of the hypoketonemic and hypoglycemic compound 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate to rats. Glucose metabolism was also assessed by measuring release of tritium from [2-T]glucose. The oxidation of long chain fatty acids was virtually suppressed in hearts from fed or starved rats given 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate while glucose utilization was increased 2-2.5 fold.",

author = "Sherratt, {H. S.A.} and Gatley, {S. J.} and DeGrado, {T. R.} and Ng, {C. K.} and Holden, {J. E.}",

note = "Funding Information: Acknowledgements: This work was supported by NIH grant thanks the Wellcome Trust for a travel grant.",

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AU - Sherratt, H. S.A.

AU - Gatley, S. J.

AU - DeGrado, T. R.

AU - Ng, C. K.

AU - Holden, J. E.

N1 - Funding Information: Acknowledgements: This work was supported by NIH grant thanks the Wellcome Trust for a travel grant.

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AB - Long-chain fatty acid oxidation by the isolated perfused rat heart was assayed by external counting using [125I]16-iodohexadecanoic acid as substrate after administration of the hypoketonemic and hypoglycemic compound 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate to rats. Glucose metabolism was also assessed by measuring release of tritium from [2-T]glucose. The oxidation of long chain fatty acids was virtually suppressed in hearts from fed or starved rats given 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate while glucose utilization was increased 2-2.5 fold.

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Effects of 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate on fatty acid and glucose metabolism in perfused rat hearts determined using iodine-125 16-iodohexadecanoate

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