Effect of topical anesthesia on episcleral venous pressure in normal human subjects

Mehrdad Malihi, Jay W. McLaren, Arthur J. Sit

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


PURPOSE. Topical anesthetics can reduce episcleral venous pressure (EVP) and IOP in rabbits. In this study, we investigated the effect of topical anesthesia on EVP in normal human subjects. METHODS. We included in this study 30 eyes of 15 healthy volunteers who were habitual soft contact lens wearers. The EVP was measured before and at 5 and 10 minutes after instillation of topical proparacaine 0.5% in one eye. The EVP was measured by using a custom objective venomanometer. We compared EVP at 5 and 10 minutes after proparacaine to EVP before instilling proparacaine. RESULTS. There was no significant difference between EVP in eyes receiving topical anesthetic at 5 or 10 minutes (7.2 ± 2.2 and 7.6 ± 2.7 mm Hg, respectively; mean ± SD) compared to contralateral eyes (6.9 ± 2.5 and 7.3 ± 2.6 mm Hg, respectively; P > 0.10). As well, EVP was not significantly different 5 or 10 minutes after topical anesthesia compared to baseline in either the eyes receiving anesthetic or the contralateral eyes (all P > 0.10; minimum detectable difference, 1.4–1.9 mm Hg, ɑ ¼ 0.05, β ¼ 0.20, n ¼ 30 eyes). CONCLUSIONS. The EVP in human eyes is not affected significantly by topical anesthetics.

Original languageEnglish (US)
Pages (from-to)2968-2970
Number of pages3
JournalInvestigative Ophthalmology and Visual Science
Issue number5
StatePublished - 2015


  • Aqueous humor dynamics
  • Episcleral venous pressure
  • Intraocular pressure

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Effect of topical anesthesia on episcleral venous pressure in normal human subjects'. Together they form a unique fingerprint.

Cite this