TY - JOUR
T1 - Effect of supine posture on airway blood flow and pulmonary function in stable heart failure
AU - Ceridon, Maile L.
AU - Morris, Norman R.
AU - Olson, Thomas P.
AU - Lalande, Sophie
AU - Johnson, Bruce D.
N1 - Funding Information:
The authors would like to thank the subjects for their participation in our study and contributions of Jennifer Fitz-Gibbon and Dr. Lyle J. Olson in the recruitment and daily testing. We would also like to thank Dr. Kenneth C. Beck for his technical expertise and Dr. Adam Wanner for his input and guidance in setting up the airway blood flow technique in our laboratory. This study was supported by the National Institute of Health Grant [ HL71478 ].
PY - 2011/9/15
Y1 - 2011/9/15
N2 - Background: The aim of this study was to determine the relationship between body position, pulmonary function (PF) and bronchial blood flow (Q aw) in a group of heart failure (HF) and control subjects. Methods: Thirty-six subjects were studied: 24 stable, ambulatory HF patients (HF: LVEF = 27. ±. 6%, age = 65. ±. 9 yr) and 12 age- and sex-matched controls (CTRL: LVEF = 60. ±. 7%, age = 62. ±. 8 yr). Measures of Q̇aw (soluble gas method) and PF were collected upright and following 30 min in the supine position. Results: Q̇aw was similar between groups and remained unchanged with body position. Declines in forced vital capacity (FVC) and forced expiratory volume in 1s (FEV 1) with the supine position were observed in both groups; declines in forced expiratory flow 25-75% (FEF 25-75) and FEF 75% (FEF 75) with the supine position were observed in the HF group only. Changes in Q̇aw were related to changes in PF only in the HF patient groups (ΔFVC, % predicted, r=-0.45, p<0.04, ΔFEV 1 r=-0.61, p<0.01, ΔFEV 1% predicted, r=-0.45, p<0.04). Conclusion: These data demonstrate that relationships between postural changes in Q̇aw and PF exist only in the HF population and that the bronchial circulation may contribute to postural PF decline in HF.
AB - Background: The aim of this study was to determine the relationship between body position, pulmonary function (PF) and bronchial blood flow (Q aw) in a group of heart failure (HF) and control subjects. Methods: Thirty-six subjects were studied: 24 stable, ambulatory HF patients (HF: LVEF = 27. ±. 6%, age = 65. ±. 9 yr) and 12 age- and sex-matched controls (CTRL: LVEF = 60. ±. 7%, age = 62. ±. 8 yr). Measures of Q̇aw (soluble gas method) and PF were collected upright and following 30 min in the supine position. Results: Q̇aw was similar between groups and remained unchanged with body position. Declines in forced vital capacity (FVC) and forced expiratory volume in 1s (FEV 1) with the supine position were observed in both groups; declines in forced expiratory flow 25-75% (FEF 25-75) and FEF 75% (FEF 75) with the supine position were observed in the HF group only. Changes in Q̇aw were related to changes in PF only in the HF patient groups (ΔFVC, % predicted, r=-0.45, p<0.04, ΔFEV 1 r=-0.61, p<0.01, ΔFEV 1% predicted, r=-0.45, p<0.04). Conclusion: These data demonstrate that relationships between postural changes in Q̇aw and PF exist only in the HF population and that the bronchial circulation may contribute to postural PF decline in HF.
KW - Bronchial blood flow
KW - Left ventricular systolic dysfunction
KW - Upright and supine position
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U2 - 10.1016/j.resp.2011.06.021
DO - 10.1016/j.resp.2011.06.021
M3 - Article
C2 - 21741500
AN - SCOPUS:80052358038
SN - 1569-9048
VL - 178
SP - 269
EP - 274
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
IS - 2
ER -