Effect of rapid colonic transit on stool microbiome and short-chain fatty acids in diarrhoea-predominant irritable bowel syndrome

Joelle Bousaba; Ting Zheng; Saam Dilmaghani; Stephen Johnson; Jun Chen; Michael Camilleri

doi:10.1136/gutjnl-2022-329359

Effect of rapid colonic transit on stool microbiome and short-chain fatty acids in diarrhoea-predominant irritable bowel syndrome

Joelle Bousaba, Ting Zheng, Saam Dilmaghani, Stephen Johnson, Jun Chen, Michael Camilleri

Research output: Contribution to journal › Letter › peer-review

Abstract

In a recent article in GUT,1 we showed that, among 194 patients with diarrhoea-predominant irritable bowel syndrome (IBS-D), 43 had altered bile acid (BA) metabolism (ABAM) (serum 7αC4>52 ng/mL). Patients with ABAM, had faster colonic transit (CT), lower α diversity and a different microbial compositional profile based on β diversity compared with IBS-D without ABAM. There were no significant differences in the stool short-chain fatty acid (SCFA) concentrations between the two groups.1 There is evidence that transit impacts gut microbiome composition and diversity.2

Original language	English (US)
Pages (from-to)	375-376
Number of pages	2
Journal	Gut
Volume	73
Issue number	2
DOIs	https://doi.org/10.1136/gutjnl-2022-329359
State	Published - Jan 19 2023

ASJC Scopus subject areas

Gastroenterology

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title = "Effect of rapid colonic transit on stool microbiome and short-chain fatty acids in diarrhoea-predominant irritable bowel syndrome",

abstract = "In a recent article in GUT,1 we showed that, among 194 patients with diarrhoea-predominant irritable bowel syndrome (IBS-D), 43 had altered bile acid (BA) metabolism (ABAM) (serum 7αC4>52 ng/mL). Patients with ABAM, had faster colonic transit (CT), lower α diversity and a different microbial compositional profile based on β diversity compared with IBS-D without ABAM. There were no significant differences in the stool short-chain fatty acid (SCFA) concentrations between the two groups.1 There is evidence that transit impacts gut microbiome composition and diversity.2",

author = "Joelle Bousaba and Ting Zheng and Saam Dilmaghani and Stephen Johnson and Jun Chen and Michael Camilleri",

note = "Funding Information: This work was supported by grant R01-DK115950 from National Institutes of Health (MC). Publisher Copyright: {\textcopyright} 2023 Author(s). Published by BMJ.",

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T1 - Effect of rapid colonic transit on stool microbiome and short-chain fatty acids in diarrhoea-predominant irritable bowel syndrome

AU - Bousaba, Joelle

AU - Zheng, Ting

AU - Dilmaghani, Saam

AU - Johnson, Stephen

AU - Chen, Jun

AU - Camilleri, Michael

PY - 2023/1/19

Y1 - 2023/1/19

N2 - In a recent article in GUT,1 we showed that, among 194 patients with diarrhoea-predominant irritable bowel syndrome (IBS-D), 43 had altered bile acid (BA) metabolism (ABAM) (serum 7αC4>52 ng/mL). Patients with ABAM, had faster colonic transit (CT), lower α diversity and a different microbial compositional profile based on β diversity compared with IBS-D without ABAM. There were no significant differences in the stool short-chain fatty acid (SCFA) concentrations between the two groups.1 There is evidence that transit impacts gut microbiome composition and diversity.2

AB - In a recent article in GUT,1 we showed that, among 194 patients with diarrhoea-predominant irritable bowel syndrome (IBS-D), 43 had altered bile acid (BA) metabolism (ABAM) (serum 7αC4>52 ng/mL). Patients with ABAM, had faster colonic transit (CT), lower α diversity and a different microbial compositional profile based on β diversity compared with IBS-D without ABAM. There were no significant differences in the stool short-chain fatty acid (SCFA) concentrations between the two groups.1 There is evidence that transit impacts gut microbiome composition and diversity.2

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Effect of rapid colonic transit on stool microbiome and short-chain fatty acids in diarrhoea-predominant irritable bowel syndrome

Abstract

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