Background. This study was aimed at examining the effects of radiocontrast agents on selected membrane transport functions. Methods. The effect of diatrizoate sodium (DS), diatrizoate meglumine (DM), and diatrizoate compound (DC) on Na+/K+ pump activity and number, L-arginine, and choline transports were evaluated in erythrocytes of normal individuals and patients undergoing cardiac catheterization. Results. Normal individuals' erythrocytes potassium influxes were 1.50±0.35, 1.32±0.37, 1.28±0.30, and 1.01±0.25 mmol/L cell/h in control, DS, DM, and DC groups, respectively ( P = 0.004; DC vs. control). Patients exposure to Hypaque M-76® significantly diminished Na+/K+ pump activity (1.40±0.36 before, vs. 1.27±0.40 mmol/L cell/h after; P = 0.039). The number of Na+/K+ pumps was reduced (156±36 vs. 143±34 pumps/erythrocyte; P = 0.015) in presence of DS. L-arginine and choline transports changed only at high radiocontrast concentrations. Conclusion. Selective changes in erythrocytes membrane transport function take place on exposure to radiocontrasts.
- Erythrocyte membrane
- Na/K pump
- Radiocontrast toxicity
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine