Effect of pramipexole in treatment of resistant restless legs syndrome

Siong Chi Lin, Joseph Kaplan, Charles D. Burger, Paul A. Fredrickson

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


Objective: To report the results of an open-label trial with a dopaminergic agent, pramipexole, in patients with treatment-resistant restless legs syndrome (RLS). Material and Methods: We studied the response to pramipexole in a consecutive series of 16 patients with symptomatic RLS who had previously experienced failure with other dopaminergic therapies. Patients assessed their posttreatment change in symptoms of RLS on a visual analog scale and indicated drug-related side effects with use of a checklist. Results: With a mean dose of pramipexole of 0.3 mg, most patients reported clinically significant improvement. From 2 to 3 months after initiation of pramipexole therapy, nocturnal leg restlessness, involuntary leg movements, and insomnia had decreased in 12, 10, and 11 patients, respectively. The most frequent adverse effects were fatigue and stiffness, which occurred in a third of the patients. Overall, the drug was well tolerated. Conclusion: On the basis of these findings, we propose that pramipexole, a D2 subgroup receptor agonist, is an effective agent for treatment of RLS.

Original languageEnglish (US)
Pages (from-to)497-500
Number of pages4
JournalMayo Clinic proceedings
Issue number6
StatePublished - 1998

ASJC Scopus subject areas

  • General Medicine


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