Effect of gadolinium-DTPA on the magnetic relaxation times of normal and infarcted myocardium

G. E. Wesbey, C. B. Higgins, M. T. McNamara, B. L. Engelstad, M. J. Lipton, R. Sievers, R. L. Ehman, J. Lovin, R. C. Brasch

Research output: Contribution to journalArticlepeer-review

133 Scopus citations


Acute myocardial infarctions were produced in 11 dogs by ligation of the left anterior descending coronary artery. Twenty-four hours after ligation, 0.35 millimoles per kilogram of Gd-DTPA was injected intravenously, followed by cardiectomy either 90 seconds (3 dogs) or 5 minutes (5 dogs) later. The remaining 3 dogs had cardiectomy without injection of Gd-DTPA at 24 hours after coronary occlusion. The 3 dogs that did not receive Gd-DTPA had longer T1 and T2 relaxation times in infarcted myocardium than in normal myocardium, as measured by a 10.7-MHz magnetic resonance (MR) spectrometer. The T1 and T2 relaxation times of normal myocardium at 90 seconds postinjection of Gd-DTPA were significantly shorter (p < 0.05) than those of the normal myocardium of animals that did not receive Gd-DTPA. At five minutes postinjection, significantly (p < 0.01) greater T1 shortening was exhibited in the infarcted myocardium compared with adjacent normal myocardium in the dogs injected with Gd-DTPA. Thus, Gd-DTPA has differential and time-varying effects on relaxation times of normal and infarcted myocardium.

Original languageEnglish (US)
Pages (from-to)165-169
Number of pages5
Issue number1
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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