Effect of cerebroventricular perfusion of bombesin on gastrointestinal myoelectric activity

M. Hashmonai, J. H. Szurszewski

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The effect of intracerebroventricular (ICV) perfusion of bombesin (BBS) on the interdigestive migrating myoelectric complex (MMC) activity was examined in conscious dogs with electrodes implanted on the stomach and small intestine. Cannulas and a catheter were chronically positioned in the lateral and fourth cerebral ventricles, respectively. ICV perfusion of BBS, which failed to increase plasma BBS levels, replaced phase I activity in the stomach and duodenum by intense irregular spike activity and decreased the occurrence rate of MMCs, whereas intravenous infusion of BBS evoked phase II- like activity, mainly in the jejunum and ileum, and suppressed phase III activity. These data suggest that the effect of ICV administration of BBS was mediated by direct activation of central brain structures. During ICV perfusion of BBS, cycling in plasma levels of motilin persisted even when phase III activity was absent and plasma levels of epinephrine rose significantly. Epinephrine infusion, however, did not affect myoelectric gastrointestinal activity except for prolonging phase II. Thus it is unlikely that the central action of BBS is exerted by motilin or epinephrine.

Original languageEnglish (US)
Pages (from-to)G677-G686
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Issue number4 37-4
StatePublished - Apr 1998


  • Epinephrine
  • Intravenous infusion of bombesin

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)


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