Effect of artificial pancreas treatment on peripheral nerve function in diabetes

F. J. Service, J. R. Daube, P. C. O'Brien, P. J. Dyck

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


To determine whether the complete correction of hyperglycemia of diabetes can rapidly improve abnormal peripheral nerve function, eight hyperglycemic insulin-requiring diabetics underwent 3 days of glucose control with an artificial endocrine pancreas, the Biostatorb Glucose Controller. Comparison of neurologic assessment before and after BIOSTATOR treatment showed improvement only in ulnar sensory conduction velocity (+ 3.2 21.4 meters per second, p < 0.032) and no significant changes in 24 other nerve conduction measurements, computer-assisted sensory examination, and scored neurologic assessment. Any significant beneficial effect on nerve function resulting from correction of hyperglycemia probably requires more than 3 days to be manifested.

Original languageEnglish (US)
Pages (from-to)1375-1380
Number of pages6
Issue number11
StatePublished - Nov 1981

ASJC Scopus subject areas

  • Clinical Neurology


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