E/Ea is the Major Determinant of Pulmonary Artery Pressure in Moderate to Severe Aortic Stenosis

Grace Casaclang-Verzosa, Vuyisile T. Nkomo, Maurice E. Sarano, Joseph F. Malouf, Fletcher A. Miller, Jae K. Oh

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Objective: Our aim was to determine echocardiographic Doppler predictors of pulmonary artery systolic pressure (PASP) in patients with moderate to severe aortic stenosis (AS). Methods: In this retrospective study of 50 patients with moderate to severe AS, the determinants of PASP were analyzed. Results: Aortic valve area was 0.84 ± 0.3 cm2, with mean gradient of 55 ± 16 mm Hg, mean ejection fraction (EF) of 60 ± 13%, mean PASP of 37 ± 15 mm Hg, and mean E/Ea of 14 ± 6. aortic valve area and mean gradient did not predict degree of PASP and were not associated with EF and diastolic parameters. LV mass index (P = .0005), E velocity (P = .006), E/Ea (P < .0001), and EF (P < .0001) were univariately significantly associated with PASP. By multivariate analysis, E/Ea independently predicted PASP (P = .0001). Conclusion: Our findings suggest that in moderate to severe AS, diastolic function, not AS severity, determines PASP. Superimposed diastolic dysfunction likely contributes to clinical symptoms of moderate to severe AS.

Original languageEnglish (US)
Pages (from-to)824-827
Number of pages4
JournalJournal of the American Society of Echocardiography
Issue number7
StatePublished - Jul 1 2008


  • Aortic stenosis
  • Diastolic dysfunction
  • Pulmonary hypertension

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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