TY - JOUR
T1 - E/Ea is the Major Determinant of Pulmonary Artery Pressure in Moderate to Severe Aortic Stenosis
AU - Casaclang-Verzosa, Grace
AU - Nkomo, Vuyisile T.
AU - Sarano, Maurice E.
AU - Malouf, Joseph F.
AU - Miller, Fletcher A.
AU - Oh, Jae K.
PY - 2008/7
Y1 - 2008/7
N2 - Objective: Our aim was to determine echocardiographic Doppler predictors of pulmonary artery systolic pressure (PASP) in patients with moderate to severe aortic stenosis (AS). Methods: In this retrospective study of 50 patients with moderate to severe AS, the determinants of PASP were analyzed. Results: Aortic valve area was 0.84 ± 0.3 cm2, with mean gradient of 55 ± 16 mm Hg, mean ejection fraction (EF) of 60 ± 13%, mean PASP of 37 ± 15 mm Hg, and mean E/Ea of 14 ± 6. aortic valve area and mean gradient did not predict degree of PASP and were not associated with EF and diastolic parameters. LV mass index (P = .0005), E velocity (P = .006), E/Ea (P < .0001), and EF (P < .0001) were univariately significantly associated with PASP. By multivariate analysis, E/Ea independently predicted PASP (P = .0001). Conclusion: Our findings suggest that in moderate to severe AS, diastolic function, not AS severity, determines PASP. Superimposed diastolic dysfunction likely contributes to clinical symptoms of moderate to severe AS.
AB - Objective: Our aim was to determine echocardiographic Doppler predictors of pulmonary artery systolic pressure (PASP) in patients with moderate to severe aortic stenosis (AS). Methods: In this retrospective study of 50 patients with moderate to severe AS, the determinants of PASP were analyzed. Results: Aortic valve area was 0.84 ± 0.3 cm2, with mean gradient of 55 ± 16 mm Hg, mean ejection fraction (EF) of 60 ± 13%, mean PASP of 37 ± 15 mm Hg, and mean E/Ea of 14 ± 6. aortic valve area and mean gradient did not predict degree of PASP and were not associated with EF and diastolic parameters. LV mass index (P = .0005), E velocity (P = .006), E/Ea (P < .0001), and EF (P < .0001) were univariately significantly associated with PASP. By multivariate analysis, E/Ea independently predicted PASP (P = .0001). Conclusion: Our findings suggest that in moderate to severe AS, diastolic function, not AS severity, determines PASP. Superimposed diastolic dysfunction likely contributes to clinical symptoms of moderate to severe AS.
KW - Aortic stenosis
KW - Diastolic dysfunction
KW - Pulmonary hypertension
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U2 - 10.1016/j.echo.2007.12.002
DO - 10.1016/j.echo.2007.12.002
M3 - Article
C2 - 18222635
AN - SCOPUS:45849123273
SN - 0894-7317
VL - 21
SP - 824
EP - 827
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 7
ER -