Educational intervention to improve quality of care in Barrett's esophagus: the AQUIRE randomized controlled trial

Sravanthi Parasa, Michael B. Wallace, Sachin Srinivasan, Suneha Sundaram, Kevin F. Kennedy, Lucas J. Williams, Prateek Sharma

Research output: Contribution to journalArticlepeer-review


Background and Aims: Despite quality measures in upper endoscopy (EGD) for Barrett's esophagus (BE), considerable variability remains in practice among gastroenterologists. This randomized controlled trial evaluated the role of structured intensive training on the quality of EGD in BE. Methods: In this multicenter study, 8 sites (from the GI Quality Consortium) were cluster randomized (1:1) to receive AQUIRE (A Quality Improvement program in cancer care during Endoscopy) training (intervention) or continue local standard practices (control). The primary outcome was compliance with the Seattle biopsy protocol. Secondary outcomes were change in knowledge of BE detection and sampling assessed by questionnaire and dysplasia detection rate (DDR) before and after completion of the 6-month study period. Results: The intervention sites (n = 4) had 31 gastroenterologists and the control sites (n = 4) had 34. There was a significant improvement in the compliance rates with the Seattle biopsy protocol from baseline to the end of the study in the intervention sites (64.8%-73.2%, P =.002) but not in the control sites (69.5%-69.4%, P =.953). The accurate response rate on the questionnaire at the intervention sites increased from 73% at baseline to 88% after AQUIRE training (difference, 14.8%; standard deviation, 18.7; P =.008). DDR did not change significantly from baseline to 6 months in either the control or intervention groups (P =.06). Conclusions: This study confirms the capacity of a structured educational intervention to improve utilization of a standard biopsy protocol and knowledge of standards of care in BE but without significant change in DDR.

Original languageEnglish (US)
Pages (from-to)239-245.e2
JournalGastrointestinal endoscopy
Issue number2
StatePublished - Feb 2022

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology


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