Edge-Enhancing Gradient Echo MRI at 7T for detection of focal cortical dysplasia in epilepsy

Erik H. Middlebrooks; Elena Greco; Xiangzhi Zhou; Vivek Gupta; Brin E. Freund; Amit K. Agarwal; Erin M. Westerhold; Anteneh M. Feyissa; William O. Tatum; Sanjeet Grewal; Vishal Patel; Shengzhen Tao

doi:10.1016/j.ynirp.2023.100187

Edge-Enhancing Gradient Echo MRI at 7T for detection of focal cortical dysplasia in epilepsy

Erik H. Middlebrooks, Elena Greco, Xiangzhi Zhou, Vivek Gupta, Brin E. Freund, Amit K. Agarwal, Erin M. Westerhold, Anteneh M. Feyissa, William O. Tatum, Sanjeet Grewal, Vishal Patel, Shengzhen Tao

Neurology

Research output: Contribution to journal › Article › peer-review

Abstract

3D-Edge Enhancing Gradient Echo MRI (EDGE) is a promising method for identifying focal cortical dysplasia (FCD) because of its superior contrast-to-noise ratio. Gains in signal-to-noise ratio (SNR) and spatial resolution using 7T MRI should further enhance the utility of EDGE; however, the exquisite sensitivity to the optimal inversion time makes translation to 7T challenging given the extreme nonuniformities in the transmit field (B1+). By utilizing a combined MP2RAGE-EDGE sequence, the efficiency of the acquisition can be optimized to improve B1+ transmit uniformity and SNR. Using this approach, we report the first experience of using 7T EDGE MRI for the diagnosis of FCD in epilepsy, showing the feasibility of achieving high spatial resolution, SNR, and image contrast uniformity. EDGE-MP2RAGE sequence improves the detection of gray-white matter junction abnormalities associated with FCD and is a valuable, time-efficient addition to a 7T MR protocol in patients with focal epilepsy.

Original language	English (US)
Article number	100187
Journal	Neuroimage: Reports
Volume	3
Issue number	4
DOIs	https://doi.org/10.1016/j.ynirp.2023.100187
State	Published - Dec 2023

Keywords

7T MRI
EDGE
Epilepsy
Focal cortical dysplasia
MP2RAGE

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Neurology
Clinical Neurology

Access to Document

10.1016/j.ynirp.2023.100187

Cite this

@article{7e52a5f87a214ed3b58c166f9734a6e2,

title = "Edge-Enhancing Gradient Echo MRI at 7T for detection of focal cortical dysplasia in epilepsy",

abstract = "3D-Edge Enhancing Gradient Echo MRI (EDGE) is a promising method for identifying focal cortical dysplasia (FCD) because of its superior contrast-to-noise ratio. Gains in signal-to-noise ratio (SNR) and spatial resolution using 7T MRI should further enhance the utility of EDGE; however, the exquisite sensitivity to the optimal inversion time makes translation to 7T challenging given the extreme nonuniformities in the transmit field (B1+). By utilizing a combined MP2RAGE-EDGE sequence, the efficiency of the acquisition can be optimized to improve B1+ transmit uniformity and SNR. Using this approach, we report the first experience of using 7T EDGE MRI for the diagnosis of FCD in epilepsy, showing the feasibility of achieving high spatial resolution, SNR, and image contrast uniformity. EDGE-MP2RAGE sequence improves the detection of gray-white matter junction abnormalities associated with FCD and is a valuable, time-efficient addition to a 7T MR protocol in patients with focal epilepsy.",

keywords = "7T MRI, EDGE, Epilepsy, Focal cortical dysplasia, MP2RAGE",

author = "Middlebrooks, {Erik H.} and Elena Greco and Xiangzhi Zhou and Vivek Gupta and Freund, {Brin E.} and Agarwal, {Amit K.} and Westerhold, {Erin M.} and Feyissa, {Anteneh M.} and Tatum, {William O.} and Sanjeet Grewal and Vishal Patel and Shengzhen Tao",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = dec,

doi = "10.1016/j.ynirp.2023.100187",

language = "English (US)",

volume = "3",

journal = "Neuroimage: Reports",

issn = "2666-9560",

publisher = "Elsevier Inc.",

number = "4",

}

TY - JOUR

T1 - Edge-Enhancing Gradient Echo MRI at 7T for detection of focal cortical dysplasia in epilepsy

AU - Middlebrooks, Erik H.

AU - Greco, Elena

AU - Zhou, Xiangzhi

AU - Gupta, Vivek

AU - Freund, Brin E.

AU - Agarwal, Amit K.

AU - Westerhold, Erin M.

AU - Feyissa, Anteneh M.

AU - Tatum, William O.

AU - Grewal, Sanjeet

AU - Patel, Vishal

AU - Tao, Shengzhen

PY - 2023/12

Y1 - 2023/12

N2 - 3D-Edge Enhancing Gradient Echo MRI (EDGE) is a promising method for identifying focal cortical dysplasia (FCD) because of its superior contrast-to-noise ratio. Gains in signal-to-noise ratio (SNR) and spatial resolution using 7T MRI should further enhance the utility of EDGE; however, the exquisite sensitivity to the optimal inversion time makes translation to 7T challenging given the extreme nonuniformities in the transmit field (B1+). By utilizing a combined MP2RAGE-EDGE sequence, the efficiency of the acquisition can be optimized to improve B1+ transmit uniformity and SNR. Using this approach, we report the first experience of using 7T EDGE MRI for the diagnosis of FCD in epilepsy, showing the feasibility of achieving high spatial resolution, SNR, and image contrast uniformity. EDGE-MP2RAGE sequence improves the detection of gray-white matter junction abnormalities associated with FCD and is a valuable, time-efficient addition to a 7T MR protocol in patients with focal epilepsy.

AB - 3D-Edge Enhancing Gradient Echo MRI (EDGE) is a promising method for identifying focal cortical dysplasia (FCD) because of its superior contrast-to-noise ratio. Gains in signal-to-noise ratio (SNR) and spatial resolution using 7T MRI should further enhance the utility of EDGE; however, the exquisite sensitivity to the optimal inversion time makes translation to 7T challenging given the extreme nonuniformities in the transmit field (B1+). By utilizing a combined MP2RAGE-EDGE sequence, the efficiency of the acquisition can be optimized to improve B1+ transmit uniformity and SNR. Using this approach, we report the first experience of using 7T EDGE MRI for the diagnosis of FCD in epilepsy, showing the feasibility of achieving high spatial resolution, SNR, and image contrast uniformity. EDGE-MP2RAGE sequence improves the detection of gray-white matter junction abnormalities associated with FCD and is a valuable, time-efficient addition to a 7T MR protocol in patients with focal epilepsy.

KW - 7T MRI

KW - EDGE

KW - Epilepsy

KW - Focal cortical dysplasia

KW - MP2RAGE

UR - http://www.scopus.com/inward/record.url?scp=85171762949&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85171762949&partnerID=8YFLogxK

U2 - 10.1016/j.ynirp.2023.100187

DO - 10.1016/j.ynirp.2023.100187

M3 - Article

AN - SCOPUS:85171762949

SN - 2666-9560

VL - 3

JO - Neuroimage: Reports

JF - Neuroimage: Reports

IS - 4

M1 - 100187

ER -

Edge-Enhancing Gradient Echo MRI at 7T for detection of focal cortical dysplasia in epilepsy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this